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SRP5220

Sigma-Aldrich

KAT8 (2-467), GST tagged human

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

FLJ14040, KAT8, MOF, MYST1, hMOF

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About This Item

CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

mol wt

~83 kDa

NCBI accession no.

application(s)

cell analysis

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... KAT8(84148)

General description

Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). MYST1 has a chromodomain that is involved in protein-protein interactions and targeting transcriptional regulators to the chromatin.

Biochem/physiol Actions

Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) was originally isolated as a human immunodeficiency virus-1 (HIV-1) TAT-interactive protein, which plays important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. MYST1 is also involved in ataxia-telangiectasia mutated (ATM) function. It acetylates histone 4-lysine 16 (H4K16). The protein is a modulator of embryonic stem cells and an epigenetic regulator. It has been associated with gastric carcinoma.

Physical form

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells.
Mu X
Cellular Reprogramming, 17(4), 259-267 (2015)
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Gupta A
Cell Reports, 8(1), 177-189 (2014)
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L
International Journal of Oncology, 46(6), 2535-2545 (2015)
Mof (MYST1 or KAT8) is essential for progression of embryonic development past the blastocyst stage and required for normal chromatin architecture.
Thomas T
Molecular and Cellular Biology, 28(16), 5093-5105 (2008)
Arun Gupta et al.
Molecular and cellular biology, 25(12), 5292-5305 (2005-06-01)
We have determined that hMOF, the human ortholog of the Drosophila MOF gene (males absent on the first), encoding a protein with histone acetyltransferase activity, interacts with the ATM (ataxia-telangiectasia-mutated) protein. Cellular exposure to ionizing radiation (IR) enhances hMOF-dependent acetylation

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