SML0364

RAD51 Inhibitor B02

≥98% (HPLC)

• Synonym(s): 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
• Empirical Formula (Hill Notation): C₂₂H₁₇N₃O
• CAS Number: 1290541-46-6
• Molecular Weight: 339.39
• MDL number: MFCD03294274
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825366
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to dark brown
• solubility: DMSO: ≥5 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=C1C=CC=C4
• InChI: 1S/C22H17N3O/c26-22-19-10-4-5-11-20(19)24-21(13-12-17-9-6-14-23-15-17)25(22)16-18-7-2-1-3-8-18/h1-15H,16H2/b13-12+
• InChI key: GEKDQXSPTHHANP-OUKQBFOZSA-N

Description

Application

RAD51 Inhibitor B02 has been used:

• to test its effect on the polar body extrusion (PBE) rate in porcine oocytes
• for RAD51 inhibition in porcine embryos
• as RAD51 inhibitor and to test its effect on targeted nucleotide substitution (TNS) in induced pluripotent stem cells (iPSCs)

Biochem/physiol Actions

B02 (3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone), a pyridinylvinyl-quinazolinone compound is cell-permeable. B02 inhibits human RAD51 recombinase and subsequent nucleofilaments formation. It halts homologous recombination (HR) repair events in cancer cells. B02 favors apoptosis in multiple myeloma and is crucial for sensitizing them to doxorubicin.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable