C1538

Complement C8 deficient serum human

for complement assays

• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: human
• Quality Level: 200
• form: solution
• origin: USA origin
• technique(s): activity assay: suitable
• impurities: infectious agent, tested
• UniProt accession no.: P07357
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... C8A(731)

Description

Application

Complement C8 is one of the end terminals of the complement system contained in the membrane attack complex (MAC). A deficiency of C8 may result in an increased susceptibility to Neisseria meningitidis. The most common mutation resulting in a C8 deficiency is a C to T transition in exon 9 of the C8 beta gene. Recent research however, has also discovered that two separate heterogeneous mutations may result in C8 deficiency in patients displaying recurrent meningococcal meningitis. These mutations are a duplication mutation on exon 7 and a mutation on exon 3.

Biochem/physiol Actions

Serum naturally deficient in C8 may actually contain some C8, though in greatly reduced quantity. Terminal complement complex is present at trace levels in such sera.

Physical form

Supplied as a solution in PBS, pH 7.3

Analysis Note

C8 is depleted by immunoadsorption as judged by a highly sensitive hemolytic assay.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable