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Key Documents

A3669

Supelco

Acebutolol hydrochloride

analytical standard

Synonym(s):

N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide

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About This Item

Empirical Formula (Hill Notation):
C18H28N2O4 · HCl
CAS Number:
Molecular Weight:
372.89
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

storage temp.

2-8°C

SMILES string

Cl.CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(C)=O

InChI

1S/C18H28N2O4.ClH/c1-5-6-18(23)20-14-7-8-17(16(9-14)13(4)21)24-11-15(22)10-19-12(2)3;/h7-9,12,15,19,22H,5-6,10-11H2,1-4H3,(H,20,23);1H

InChI key

KTUFKADDDORSSI-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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General description

Acebutolol hydrochloride is a β-adrenergic receptor blocker. It is used in the treatment of hypertension, cardiac arrhythmias and angina pectoris.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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2013 Nurse's Drug Handbook (2012)
The effect of acebutolol on the cerebral circulation of man.
Hares P, et al.
British Journal of Clinical Pharmacology, 4(3), 373-375 (1977)
Iu M Alekseeva et al.
Kardiologiia, 47(12), 24-34 (2008-02-12)
Beta-blocking agents (BB) decrease mortality particularly sudden in post-myocardial infarction patients and in patients with chronic heart failure that is closely related to heart rate (HR) lowering at rest. The hypothesis exists that BB decrease mortality due to increase of
Donatella Ottaviani et al.
Journal of medical microbiology, 62(Pt 1), 161-164 (2012-09-25)
We report a severe case of travellers' diarrhoea in a patient returning from Ecuador to Italy with the concomitant presence of Aeromonas veronii biovar sobria and Vibrio parahaemolyticus in their faeces. Based on diagnostic results, epidemiological information and the clinical
Stéphane Rinfret et al.
American heart journal, 153(2), 224-230 (2007-01-24)
Long-term treatment with beta-blockers reduces mortality after acute myocardial infarction (AMI). Whether beta-blockers exert a class effect is unknown. We analyzed mortality after AMI in Canadian patients 65 years or older who were discharged from hospital with a diagnosis of

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