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Semicarbazide hydrochloride

VETRANAL®, analytical standard

Synonym(s):

N-Aminourea hydrochloride, Hydrazine carboxamide hydrochloride

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About This Item

Linear Formula:
NH2CONHNH2 · HCl
CAS Number:
563-41-7
Molecular Weight:
111.53
Beilstein:
3593642
EC Number:
209-247-0
MDL number:
MFCD00013009
UNSPSC Code:
41116107
PubChem Substance ID:
329754605
NACRES:
NA.24

grade

analytical standard

Quality Level

100

product line

VETRANAL®

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

175-177 °C (dec.) (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

Cl.NNC(N)=O

InChI

1S/CH5N3O.ClH/c2-1(5)4-3;/h3H2,(H3,2,4,5);1H

InChI key

XHQYBDSXTDXSHY-UHFFFAOYSA-N

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Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Semicarbazide hydrochloride may be used as a stabilizing agent for the determination of norepinephrine in plasma samples using stable-isotope dilution gas chromatography-tandem mass spectrometry with negative ion chemical ionization.
Semicarbazide hydrochloride may be used in the synthesis of 4-nitrobenzaldehyde semicarbazone via reaction with 4-nitrobenzaldehyde.

Legal Information

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Statements

H301,H314,H361fd,H373

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Repr. 2 - Skin Corr. 1B - STOT RE 2 Oral

Target Organs

Bone

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG5699
BCCG5696
BCBV0190
BCBV0139
SZBD324XV

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Determination of norepinephrine in small volume plasma samples by stable-isotope dilution gas chromatography-tandem mass spectrometry with negative ion chemical ionization.
Kuhlenbeck LD, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 738(2), 319-330 (2000)
Determination of the metabolites of nitrofuran antibiotics in animal tissue by high-performance liquid chromatography?tandem mass spectrometry
Leitner A, et al.
Journal of Chromatography A, 939, 49-58 (2001)
Kazimiera Cwiek-Ludwicka
Roczniki Panstwowego Zakladu Higieny, 61(4), 341-347 (2010-01-01)
The release of the substances from food packaging into food triggers the problem for food safety and is the matter of particular interest in the European Commission (EC) and Member States. The problems concerning the presence of these substances in
Formation of semicarbazide upon hypochlorous acid treatment of nitrogen containing compounds.
B Kerkaert et al.
Communications in agricultural and applied biological sciences, 76(1), 115-118 (2011-05-05)
M P Dmytrenko et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 82(4), 86-91 (2011-04-27)
Subchronic administration of semicarbazide in the experiment with the rats was used to reduce the formaldehyde level in the organism in order to reveal the interaction between formaldehyde metabolism and biochemical parameters, which define the oxidant-antioxidant system condition and NO
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