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SCR022

Sigma-Aldrich

Adult Rat Hippocampal Neural Stem Cells

Adult Rat Hippocampal Neural Stem Cells are self-renewing cells with the capacity to differentiate into neurons, astrocytes & oligodendrocytes.

Synonym(s):

Rat Neural Stem Cells

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About This Item

UNSPSC Code:
41106509
eCl@ss:
32011203
NACRES:
NA.81

biological source

rat

Quality Level

100

manufacturer/tradename

Chemicon®

technique(s)

cell culture | stem cell: suitable

input

sample type neural stem cell(s)

shipped in

liquid nitrogen

General description

Adult Rat Hippocampal Neural Stem Cells

Introduction:

Neural stem cells (NSC) are self-renewing cells with the capacity to differentiate into neurons, astrocytes and oligodendrocytes. Adult NSC are extremely rare and are believed to reside only in discrete regions of the hippocampus and the subventricular zone. Due to their therapeutic promise, considerable attention has been focused on identifying the sources of stem cells, the signals that regulate their proliferation and the specification of neural stem cells towards more differentiated cell lineages (Gage, 2000).

Presently, neural stem cells are often identified based upon the presence of molecular markers that are correlated with the stem and/or progenitor state along with the absence of differentiated phenotypes as assessed through marker analysis. To aid researchers in the accurate identification and characterization of neural stem cells, Millipore presents cryopreserved Adult Rat Hippocampal Neural Stem Cells (Catalog No. SCR022).

Millipore′s Cryopreserved Adult Rat Hippocampal Neural Stem Cells provides ready-to use primary neural stem cells isolated from the hippocampus of adult Fisher 344 rats. These primary cells may be used for a variety of research applications including drug development, for studies of neurotoxicity, neurogenesis, electrophysiology, neurotransmitter and receptor functions and CNS diseases and disorders.

We recommend that Millipore′s Cryopreserved Adult Rat Hippocampal Neural Stem Cells (Catalog No. SCR022) be used in conjunction with the Neural Stem Cell Marker Characterization Kit (Catalog No. SCR019) and differentiation assays that demonstrate multipotentiality of the starting cell population. Please look for these differentiation assays from CHEMICON in the near future.

For Research Use Only; not for use in diagnostic procedure.

Cell Line Description

Neural Stem Cells

Application

Research Category
Stem Cell Research

Packaging

1x10(e6) cells

Components

1.1x10e6 viable Adult Rat Hippocampal Neural Stem Cells: (Part No. 2003769) derived from adult female Fisher 344 rats, aged 43-55 days, cryopreserved. Store in liquid nitrogen.

Storage and Stability

When stored at the recommended storage conditions (liquid nitrogen), adult hippocampal neural stem cells are stable up to the expiration date. Do not expose to elevated temperatures. Discard any remaining reagents after the expiration date. We recommend that the cells be used within ten passages.

Legal Information

Accutase is a registered trademark of Innovative Cell Technologies, Inc.
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sehee Kim et al.
International journal of molecular sciences, 18(9) (2017-09-12)
Palmitate concentrations in type 2 diabetic patients are higher than in healthy subjects. The prolonged elevation of plasma palmitate levels induces oxidative stress and mitochondrial dysfunction in neuronal cells. In this study, we examined the role of mdivi-1, a selective
Elizabeth D Kirby et al.
eLife, 2, e00362-e00362 (2013-04-20)
Stress is a potent modulator of the mammalian brain. The highly conserved stress hormone response influences many brain regions, particularly the hippocampus, a region important for memory function. The effect of acute stress on the unique population of adult neural
Hyunju Chung et al.
The Journal of endocrinology, 230(2), 239-250 (2016-06-22)
We have previously demonstrated that ghrelin stimulates the cellular proliferation of cultured adult rat hippocampal neural stem cells (NSCs). However, little is known about the molecular mechanisms by which ghrelin regulates cell cycle progression. The purpose of this study was
Qingfeng Li et al.
Cell & bioscience, 13(1), 183-183 (2023-10-02)
N7-methylguanosine (m7G) is one of the most conserved modifications in nucleosides impacting mRNA export, splicing, and translation. However, the precise function and molecular mechanism of internal mRNA m7G methylation in adult hippocampal neurogenesis and neurogenesis-related Alzheimer's disease (AD) remain unknown.
Hyunju Chung et al.
The Journal of endocrinology, 218(1), 49-59 (2013-04-24)
Ghrelin, an endogenous ligand for the GH secretagogue receptor (GHS-R) receptor 1a (GHS-R1a), has been implicated in several physiologic processes involving the hippocampus. The aim of this study was to investigate the molecular mechanisms of ghrelin-stimulated neurogenesis using cultured adult
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Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.

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