The product 855051 is specifically designed for this purpose.
8.55051
Biotin NovaTag® resin
Novabiochem®
Synonym(s):
N-Biotin-NÆ-Fmoc-ethylenediamine MPB-AM resin
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About This Item
UNSPSC Code:
12352209
Pricing and availability is not currently available.
Recommended Products
product line
NovaSyn® TG
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
15-25°C
General description
Biotin NovaTag resin is an ideal tool for the synthesis of peptides labeled with biotin. As the biotin moiety is incorporated into the linker, its use eliminates the problems associated with biotin-labeling of peptides, namely poor solubility and sluggish coupling kinetics of biotin and its derivatives. Following peptide assembly under standard Fmoc SPPS conditions, cleavage with TFA affords the peptide labeled with biotin. For a recent applications see [1,2].
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] M. Carraz, et al. (2009) Chemistry & Biology, 16, 702.
[2] S. Millward, et al. (2007) Chem. Biol., 2, 625.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Literature references
[1] M. Carraz, et al. (2009) Chemistry & Biology, 16, 702.
[2] S. Millward, et al. (2007) Chem. Biol., 2, 625.
Linkage
Replaces: 04-12-3901
Analysis Note
Color (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.35 - 0.65 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer metrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.35 - 0.65 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer metrix is copoly (styrene - 1% DVB), 100 - 200 mesh.
Legal Information
NOVASYN is a registered trademark of Merck KGaA, Darmstadt, Germany
NOVATAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Articles
Biotin-labelled peptides find applications in immunology and histochemistry for affinity purification and receptor localization.
Biotin-labelled peptides find applications in immunology and histochemistry for affinity purification and receptor localization.
Biotin-labelled peptides find applications in immunology and histochemistry for affinity purification and receptor localization.
Biotin-labelled peptides find applications in immunology and histochemistry for affinity purification and receptor localization.
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Is it possible to use product 8.55051 as a means to add biotin to the C-terminus of a peptide?
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