- EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis.
EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis.
Cell reports (2017-01-05)
Aurélie S Clottu, Amandine Mathias, Andreas W Sailer, Myriam Schluep, Jörg D Seebach, Renaud Du Pasquier, Caroline Pot
PMID28052250
要旨
The interaction between oxysterols and the G protein-coupled receptor Epstein-Barr virus-induced gene 2 (EBI2) fine-tunes immune cell migration, a mechanism efficiently targeted by several disease-modifying treatments developed to treat multiple sclerosis (MS), such as natalizumab. We previously showed that memory CD4
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