Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Aluminum toxicity and astrocyte dysfunction: a metabolic link to neurological disorders.

Journal of inorganic biochemistry (2011-11-22)

Joseph Lemire, Vasu D Appanna

PMID22099161

要旨

Aluminum (Al) has been implicated in a variety of neurological diseases. However, the molecular mechanisms that enable Al to be involved in these disorders have yet to be fully delineated. Using astrocytes as a model of the cerebral cellular system, we have uncovered the biochemical networks that are affected by Al toxicity. In this review, we reveal how the inhibitory influence of Al on ATP production and on mitochondrial functions help generate globular astrocytes that are fat producing machines. These biological events may be the contributing factors to Al-triggered brain disorders.

材料

製品番号

ブランド

製品内容

266558

Sigma-Aldrich

アルミニウム, wire, diam. 1.0 mm, 99.999% trace metals basis

518573

Sigma-Aldrich

アルミニウム, granular, <1 mm, 99.7% trace metals basis

266523

Sigma-Aldrich

アルミニウム, ReagentPlus^®, beads, 5-15 mm, 99.9% trace metals basis

326852

Sigma-Aldrich

アルミニウム, foil, thickness 0.25 mm, 99.999% trace metals basis

338788

Sigma-Aldrich

アルミニウム, pellets, 3-12 mm, 99.99% trace metals basis

266574

Sigma-Aldrich

アルミニウム, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis

310360

Sigma-Aldrich

アルミニウム, ACS reagent, 99%, wire, wire diam. ~1.5 mm

326860

Sigma-Aldrich

アルミニウム, foil, thickness 0.13 mm, ≥99.99% trace metals basis

326887

Sigma-Aldrich

アルミニウム, wire, diam. 0.58 mm, ≥99.99% trace metals basis

733369

Sigma-Aldrich

アルミニウム, foil, thickness 8 μm, 99% trace metals basis

GF44675781

アルミニウム, rod, 1000mm, diameter 12.7mm, 99%

266957

Sigma-Aldrich

アルミニウム, foil, thickness 1.0 mm, 99.999% trace metals basis

433705

Sigma-Aldrich

アルミニウム, evaporation slug, diam. × L 6.3 mm × 6.3 mm, 99.999% trace metals basis

326941

Sigma-Aldrich

アルミニウム, pellets, 3-8 mesh, ≥99.999% trace metals basis

GF98718935

アルミニウム, sphere, 100pcs, diameter 1.0mm, aluminum alloy 2017 precision sphere, grade 200, 95.2%

GF24569602

アルミニウム, foam, 150x150mm, thickness 30mm, bulk density 0.2g/cm³, porosity 0.93, aluminum 6101 grade, 98.5%

GF29732496

アルミニウム, tube, 200mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF94706354

アルミニウム, mesh, 150x150mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF51598761

アルミニウム, rod, 200mm, diameter 12.7mm, 99%

GF32029444

アルミニウム, rod, 100mm, diameter 12.7mm, 99%

GF26812043

アルミニウム, foam, 150x150mm, thickness 3.2mm, bulk density 0.2g/cm³, porosity 0.93, 16 pores/cm, aluminum 6101 grade, 98.5%

GF64700524

アルミニウム, rod, 1000mm, diameter 5.0mm, as drawn, 99.999%

GF51278070

アルミニウム, honeycomb, 300x300mm, thickness 10mm, cell size 3.2mm, cell wall 0.025mm, core density 0g/cm³, phenolic adhesive (resin), 99.5%

GF86830566

アルミニウム, mesh, 600x600mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF63629219

アルミニウム, tube, 500mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

GF38294646

アルミニウム, mesh, 300x300mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF40979773

アルミニウム, rod, 500mm, diameter 6.0mm, as drawn, 99.999%

GF96312326

アルミニウム, honeycomb, 600x600mm, thickness 26.5mm, cell size 6.3mm, cell wall 0.064mm, core density 0.083g/cm³, phenolic adhesive (resin), facing skin carbon fiber / epoxy, 99.9%

GF32182534

アルミニウム, wire reel, 10m, diameter 0.25mm, as drawn, 99.95+%

GF02417677

アルミニウム, tube, 100mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%