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  • Recurrent refractory Clostridium difficile colitis treated successfully with rifaximin and tigecycline: a case report and review of the literature.

Recurrent refractory Clostridium difficile colitis treated successfully with rifaximin and tigecycline: a case report and review of the literature.

Scandinavian journal of infectious diseases (2011-11-15)
Rima I El-Herte, Tania A Baban, Souha S Kanj
要旨

Clostridium difficile colitis infection is on the rise and is considerably increasing the duration of hospital stay, as well as healthcare costs. The management of C. difficile colitis has become more challenging with the increasing failure of therapeutic response to metronidazole and oral vancomycin. Tigecycline is a new glycylcycline that has shown in vitro activity against C. difficile. We report herein a case of C. difficile colitis that failed to improve on a combination of metronidazole and oral vancomycin. The patient subsequently developed a surgical abdomen secondary to refractory C. difficile colitis, but was successfully treated with a combination of rifaximin and tigecycline after she refused to undergo surgical treatment.

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Sigma-Aldrich
リファキシミン
リファキシミン, European Pharmacopoeia (EP) Reference Standard
システム適合性用リファキシミン, European Pharmacopoeia (EP) Reference Standard
Supelco
リファキシミン, VETRANAL®, analytical standard