- Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.
Resolution of methyl nonactate by Rhodococcus erythropolis under aerobic and anaerobic conditions.
Organic letters (2006-01-27)
Jasmina Nikodinovic, Jennifer M Dinges, Stephen C Bergmeier, Mark C McMills, Dennis L Wright, Nigel D Priestley
PMID16435855
要旨
[reaction: see text]. An efficient resolution of methyl nonactate is reported by biotransformation in shake flask cultures of Rhodococcus erythropolis. The equilibrium of the reaction redox system can be manipulated by switching from aerobic to anaerobic growth, thereby generating both enantiomers of the target in excellent yield and enantiomeric purity.