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  • Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1).

Antiproliferative and antiplasmodial dimeric phloroglucinols from Mallotus oppositifolius from the Madagascar Dry Forest (1).

Journal of natural products (2013-01-05)
Liva Harinantenaina, Jessica D Bowman, Peggy J Brodie, Carla Slebodnick, Martin W Callmander, Etienne Rakotobe, Richard Randrianaivo, Vincent E Rasamison, Alexander Gorka, Paul D Roepe, Maria B Cassera, David G I Kingston
要旨

Bioassay-guided fractionation of an ethanol extract of the leaves and inflorescence of Mallotus oppositifolius collected in Madagascar led to the isolation of the two new bioactive dimeric phloroglucinols mallotojaponins B (1) and C (2), together with the known mallotophenone (3). The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, mass spectrometry, and an X-ray crystal structure. Compounds 1 and 2 showed potent antimalarial activity against chloroquine-resistant Plasmodium falciparum, with IC50 values of 0.75 ± 0.30 and 0.14 ± 0.04 μM, while 3 was inactive in this assay. Compounds 1-3 also displayed strong antiproliferative activity against the A2780 human ovarian cancer cell line (IC50 1.10 ± 0.05, 1.3 ± 0.1 and 6.3 ± 0.4 μM, respectively).

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
フロログルシノール, ≥99.0% (HPLC)
Sigma-Aldrich
フロログルシノール, suitable for plant cell culture, BioReagent
Sigma-Aldrich
フロログルシノール, Used to detect the presence of wood fiber.