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Merck

Isoprenoids: remarkable diversity of form and function.

Lipids (2004-09-11)
Sarah A Holstein, Raymond J Hohl
要旨

The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C-10 mono-, C-15 sesqui-, and C-20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranyl pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the beta-HMG-CoA reductase and Ras-related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.

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製品内容

Sigma-Aldrich
ゲラニルピロリン酸 アンモニウム塩, 1 mg/mL in methanol (:aqueous 10 mM NH4OH (7:3)), ≥95% (TLC)
Sigma-Aldrich
ゲラニルピロリン酸 リチウム塩, ≥95.0% (TLC)
Supelco
ゲラニルピロリン酸 リチウム塩, analytical standard