- A convenient synthesis of glycosyl chlorides from sugar hemiacetals using triphosgene as the chlorine source.
A convenient synthesis of glycosyl chlorides from sugar hemiacetals using triphosgene as the chlorine source.
Carbohydrate research (2000-11-10)
R M Cicchillo, P Norris
PMID11072851
要旨
Treating partially protected sugar hemiacetals with triphosgene in THF results in the formation of glycosyl chlorides. The method is compatible with acid-sensitive isopropylidene protecting groups in the hemiacetal substrates.