コンテンツへスキップ
Merck

Inhibitors of osteoclast differentiation from Cephalotaxus koreana.

Journal of natural products (2007-11-13)
Kee Dong Yoon, Doc Gyun Jeong, Yun Ha Hwang, Jei Man Ryu, Jinwoong Kim
要旨

Three new flavonoid glycosides ( 1- 3), 11-hydroxyhainanolidol ( 4), and a new dibenzylbutyrolactone lignan glycoside ( 5) were isolated from the aerial parts of Cephalotaxus koreana Nakai, along with 19 known flavonoids. The structures of the new compounds were elucidated using spectroscopic evidence, primarily NMR and MS. Twenty-four compounds were isolated, and among these isoscutellarein 5-O-beta-D-glucopyranoside ( 3), apigenin ( 6), kaempferol 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside ( 7), tamarixetin 3-O-alpha-L-rhamnopyranosyl(1'''-->6'')-beta-D-glucopyranoside ( 8), quercetin 3-O-[6''-O-acetyl]-beta-D-glucopyranoside ( 9), and quercetin 3-O-alpha-L-rhamnopyranoside ( 10) showed significant inhibitory activities against osteoclast differentiation at concentrations of 0.1 and 1.0 microg/mL.

材料
製品番号
ブランド
製品内容

Sigma-Aldrich
ケンフェロール, ≥97.0% (HPLC)
Sigma-Aldrich
アピゲニン, ≥95.0% (HPLC)
Sigma-Aldrich
ケンフェロール, ≥90% (HPLC), powder
ケルセチン 3-ラムノシド, primary reference standard