フォーム
solid
色
white
溶解性
0.1 M NaOH: 7.2 mg/mL
DMSO: insoluble
H2O: insoluble
ethanol: insoluble
SMILES記法
[H]C1=CN(C[C@H](N)C(O)=O)C(=O)NC1=O
遺伝子情報
human ... GRIA1(2890) , GRIA2(2891) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901)
類似した製品をお探しですか？ 訪問 製品比較ガイド
生物化学的／生理学的作用
AMPA/kainate glutamate receptor agonist.
保管分類コード
11 - Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
最新バージョンのいずれかを選択してください：
N K Thomas et al.
Neuropharmacology, 37(10-11), 1223-1237 (1998-12-16)
The objectives of this study, conducted on neonatal rat spinal cord and dorsal roots in vitro, were to characterise the actions of a range of willardiine analogues on GluR5-containing kainate receptors present in dorsal roots, to determine whether GluR5-containing receptors
Nigel P Dolman et al.
Journal of medicinal chemistry, 50(7), 1558-1570 (2007-03-14)
Some N3-substituted analogues of willardiine such as 11 and 13 are selective kainate receptor antagonists. In an attempt to improve the potency and selectivity for kainate receptors, a range of analogues of 11 and 13 were synthesized with 5-substituents on
Kimberly A Mankiewicz et al.
Biochemistry, 47(1), 398-404 (2007-12-18)
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, one subtype in the family of ionotropic glutamate receptors, are the main receptors responsible for excitatory signaling in the mammalian central nervous system. Previous studies utilitizing the isolated ligand binding domain of these receptors have provided
Swarna Ramaswamy et al.
The Journal of biological chemistry, 287(52), 43557-43564 (2012-11-02)
We have investigated the range of cleft closure conformational states that the agonist-binding domains of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors occupy when bound to a series of willardiine derivatives using single-molecule FRET. These studies show that the agonist-binding domain exhibits
Michael K Fenwick et al.
Journal of molecular biology, 378(3), 673-685 (2008-04-05)
Glutamate receptors mediate neuronal intercommunication in the central nervous system by coupling extracellular neurotransmitter-receptor interactions to ion channel conductivity. To gain insight into structural and dynamical factors that underlie this coupling, solution NMR experiments were performed on the bilobed ligand-binding
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）