V7389

抗VAMP-8 (N-末端) ウサギ宿主抗体

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: 抗エンドブレビン抗体, 抗小胞結合膜タンパク質 8抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~14 kDa
• 化学種の反応性: human
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1.5 mg/mL
• テクニック: western blot: 0.25-0.5 μg/mL using HEK-293T cells expressing human VAMP8.
• UniProtアクセッション番号: Q9BV40
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... VAMP8(8673) ; mouse ... Vamp8(22320) ; rat ... Vamp8(83730)

詳細

詳細

Vesicle-associated membrane protein 8 (VAMP-8/endobrevin) is located at 2p11.2 on the human chromosome.

免疫原

ヒトVAMP8のN末端に位置するアミノ酸1-16に相当する合成ペプチドのKLH結合体。この配列は、マウスおよびラットVAMP8において高度に保存されています(約75%)。

アプリケーション

Anti-VAMP-8 (N-terminal) antibody has been used in immunoblotting, western blotting.

生物化学的／生理学的作用

Vesicle-associated membrane protein 8 (VAMP-8/endobrevin) is as an endosomal v-SNARE (vesicles or granules-soluble NSF attachment protein receptors) involved in fusion between early and late endosomes. It can interact with syntaxin-7, syntaxin-8, and Vti1b (Vesicle transport through interaction with t-SNAREs homolog 1B) to form an endosomal fusion complex. VAMP8 interacts with syntaxin-2 and is involved in the terminal step of cytokinesis in mammalian cells. VAMP8 is the major vesicular v-SNARE of zymogen granules from pancreatic acinar cells and has been shown to be a general vesicular SNARE for regulated exocytosis of the exocrine system. For platelet release reaction VAMP8 is the primary v-SNARE.

物理的形状

0.01 M PBS溶液 (pH 7.4, 15 mM アジ化ナトリウム含有)。

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)