U7258

Anti-Ubiquilin ウサギ宿主抗体

~0.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: Anti-DA41, Anti-DSK2, Anti-Protein-linking IAP to cytoskeleton 1, PLIC-1, Anti-UBQLN1, Anti-XDRP1
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~62 kDa
• 化学種の反応性: human
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~0.5 mg/mL
• テクニック: western blot: 0.5-1.0 μg/mL using lysates of HEK-293T cells and COS7 cells expressing human ubiquilin-1.
• UniProtアクセッション番号: Q9UMX0
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... UBQLN1(29979)

詳細

詳細

Ubiquilin-1 (UBQLN1) is a ubiquitin-like (UBL) protein, that contains UBL and ubiquitin-associated (UBA) domains in its N- and C-termini, respectively. UBQLN1 gene is located on the human chromosome at 9q21.32.

特異性

Anti-Ubiquilin-1 specifically recognizes human ubiquilin-1.

アプリケーション

Anti-Ubiquilin-1 antibody produced in rabbit has been used in:

• immunoblotting
• immunohistochemistry
• immunofluorescence

生物化学的／生理学的作用

Ubiquilin-1 (UBQLN1) protein plays a major role in regulating the proteasomal degradation of several proteins including the presenilins PS1 and PS2. This protein is also involved in the degradation of cyclin A, γ-aminobutyric acid (GABA) receptor, and hepatitis C virus RNA-dependent RNA polymerase proteins. This protein might play a general role in neurodegenerative diseases. UBQLN1 genetic variants are associated with an increased risk of Alzheimer′s disease (AD). Downregulation of UBQLN1 gene modulates PS1 endoproteolysis. Downregulation of this gene is also involved in regulating the protein levels of nicastrin and presenilin enhancer 2 (PEN-2). It also increases the rate of β-amyloid precursor proteins (APP) maturation and trafficking through the secretory pathway associated with increased production of secretory β-amyloid precursor proteins (sAPP) and amyloid β (Aβ). UBQLN1 protein is associated with neurofibrillary tangles in AD brain and Lewy bodies in Parkinson′s disease (PD).

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

保管および安定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves