由来生物
goat
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
lyophilized powder
化学種の反応性
human, pig
テクニック
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
neutralization: suitable
western blot: 0.1-0.2 μg/mL
UniProtアクセッション番号
アプリケーション
research pathology
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TGFB2(7042)
詳細
Transforming Growth Factor-β 2 (TGF-β 2) is a protein produced by many cells and is found in the highest concentration in mammalian bone and porcine platelets. In body fluids like breast milk, amniotic fluid as well as the aqueous and vitreous humor of the eye, the prominent form exist is Latent TGF-β2. It has a pivotal role in regulating invasion in high-grade gliomas by inducing mesenchymal phenotype and remodeling the extracellular matrix. Anti-Transforming Growth Factor-β2 antibody can be used in neutralization and immunohistochemistry. Goat anti-TGF-β 2 antibody reacts specifically with human and porcine TGF-β 2 and TGF-β 1.2. The product has also shown less than 2% cross-reactivity for TGF-β 1, TGF-β 3 and TGF-β 5.
特異性
本抗体は、TGF-β2およびTGF-β1.2を認識します。イムノブロッティング(非還元条件)およびELISAにおいて、TGF-β1, TGF-β3, TGF-β5との交差反応性は2%未満です。
免疫原
ブタ形質転換増殖因子β2
アプリケーション
Anti-Transforming Growth Factor-β2 antibody can be used in western blotting and ELISA.
物理的形状
凍結乾燥品(PBS溶液, 5%トレハロ-ス含有, 0.2μmフィルタ-濾過済み)
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
T4442-.1MG:
T4442-.1MG-PW:
T4442-VAR:
T4442-BULK:
Elisabetta Polazzi et al.
Journal of neurochemistry, 110(2), 545-556 (2009-05-22)
Microglia, the immune cells of the CNS, play essential roles in both physiological and pathological brain states. Here we have used an in vitro model to demonstrate neuroprotection of a 48 h-microglial conditioned medium (MCM) towards cerebellar granule neurons (CGNs)
A B Roberts et al.
Molecular reproduction and development, 32(2), 91-98 (1992-06-01)
The TGF-beta's are multifunctional, pleiotropic molecules with major effects in control of cellular migration, cellular proliferation, and elaboration of extracellular matrix. Thus far, five distinct isoforms of TGF-beta have been described, each approximately 65-85% homologous and containing the characteristic 9
Fusun Baumann et al.
Neuro-oncology, 11(4), 368-380 (2008-11-27)
Lactate dehydrogenase type A (LDH-A) is a key metabolic enzyme catalyzing pyruvate into lactate and is excessively expressed by tumor cells. Transforming growth factor-beta2 (TGF-beta2) is a key regulator of invasion in high-grade gliomas, partially by inducing a mesenchymal phenotype
Lei Hong et al.
Cell death & disease, 11(8), 695-695 (2020-08-23)
Endothelial to mesenchymal transition (EndMT) is an important pathological change in many diseases. Semaphorin7A (Sema7A) has been reported to regulate nerve and vessel homeostasis, but its role in EndMT remains unclear. Here we investigate the effect of Sema7A on EndMT
Gaurav K Keshri et al.
PloS one, 11(11), e0166705-e0166705 (2016-11-20)
Chronic non-healing cutaneous wounds are often vulnerable in one or more repair phases that prevent normal healing and pose challenges to the use of conventional wound care modalities. In immunosuppressed subject, the sequential stages of healing get hampered, which may
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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