T3702

Anti-TMP21 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• 別名: Anti-TMED10, transmembrane emp24-like trafficking protein 10, Anti-Transmembrane protein Tmp21 21 kDa, Anti-Transmembrane trafficking protein, Anti-p24delta
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~21 kDa
• 化学種の反応性: rat (predicted), human, mouse (predicted)
• 包装: antibody small pack of 25 μL
• 濃度: ~1.0 mg/mL
• テクニック: western blot: 1-2 μg/mL using HepG2 cell lysate
• UniProtアクセッション番号: P49755
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TMED10(10972) ; mouse ... Tmed10(68581) ; rat ... Tmed10(84599)

詳細

詳細

Transmembrane protein, 21KD (TMP21) gene is mapped on the human chromosome at 14q24.3. TMP21 belongs to the p24 family and is a type I transmembrane protein. It is located in the endoplasmic reticulum (ER) and the Golgi apparatus.

特異性

Anti-TMP21 (N-terminal) specifically recognizes human TMP21.

アプリケーション

Anti-TMP21 (N-terminal) antibody produced in rabbit may be used in immunoblotting.

生物化学的／生理学的作用

Transmembrane protein, 21KD (TMP21) has been recently linked to the metabolism of Alzheimer′s disease amyloid β (Ab) peptide. It is a member of the heteromeric secretase complex that distinctively regulates γ-secretase cleavage without affecting its ε-secretase cleavage. TMP21 is destabilized from the complex in the absence of the presenilins PS1, PS2, and pen-2. It might modulate intramembrane proteolysis controlling g-secretase activity and thus preventing the over-production of Ab peptide. Overexpression of TMP21 gene does not alter γ -secretase activity, but suppression of TMP21 gene increases Aβ40 and Aβ42 peptides. TMP21 appears to be independent of its role in protein transport from the endoplasmic reticulum (ER) to the Golgi and are involved in vesicular trafficking.

物理的形状

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)