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About This Item
実験式（ヒル表記法）:
C18H23IN2O2
CAS番号:
分子量:
426.29
MDL番号:
UNSPSCコード:
12352200
PubChem Substance ID:
形状
solid
色
white
溶解性
H2O: soluble
ethanol: soluble
保管温度
−20°C
SMILES記法
[I-].C[N+]1(C)C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
遺伝子情報
human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)
アプリケーション
3-Tropanylindole-3-carboxylate methiodide was used to study the role of 5-HT3 receptor-mediated cell signaling in mouse interstitial cells of Cajal and in cocaine-induced aggressive behavior in hamsters.
生物化学的／生理学的作用
3-Tropanylindole-3-carboxylate methiodide is an antagonist of 5-HT3 receptor that has antiemetic effects. It modulates the pacemaker activities of the mouse small intestine cells. It regulates the aggressive behavior induced by cocaine in hamsters.
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
[3H]quaternised ICS 205-930 labels 5-HT3 receptor binding sites in rat brain.
K J Watling et al.
European journal of pharmacology, 149(3), 397-398 (1988-05-10)
Pawan Kumar Shahi et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 15(3), 129-135 (2011-08-24)
In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions of 5-HT on pacemaker activities were investigated using a whole-cell
K J Watling et al.
European journal of pharmacology, 182(3), 465-472 (1990-07-17)
Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised ICS 205-930 to 5-HT3 receptor sites in rat cortical membranes, possessing a pKi value of 7.0. In contrast, several
Lesley A Ricci et al.
Behavioural brain research, 156(1), 19-29 (2004-10-12)
Hamsters repeatedly exposed to cocaine during adolescence display high levels of offensive aggression compared to saline-treated littermates. The escalated offensive phenotype observed in adolescent cocaine-treated animals is modulated by serotonin (5-HT) signaling and can be suppressed by inhibiting 5-HT type
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