SRP0400

PRMT4 peptide, biotin

≥90% (HPLC)

• UNSPSCコード: 12352202
• NACRES: NA.32

特性

• アッセイ: ≥90% (HPLC)
• 形状: aqueous solution
• 包装: pkg of 80 nmol
• 濃度: 400 μM
• UniProtアクセッション番号: Q86X55
• 輸送温度: dry ice
• 保管温度: −70°C
• 遺伝子情報: human ... CARM1(10498)

詳細

詳細

Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.

アプリケーション

Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.

生物化学的／生理学的作用

Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.

物理的形状

Supplied in a TRIS-buffered solution.

その他情報

200 μL at 400 μM, or 80 nmol. Sold as 80 nmol

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable