SML2145

TD52

≥98% (HPLC)

• 別名: N2,N3-bis(3-Ethynylphenyl)-2,3-quinoxalinediamine
• 実験式（ヒル表記法）: C₂₄H₁₆N₄
• CAS番号: 1798328-24-1
• 分子量: 360.41
• UNSPSC Code: 12352200
• NACRES: NA.77
• eCl@ss: 32160702
• Assay: ≥98% (HPLC)
• Form: powder

特性

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: C#CC1=CC=CC(NC2=NC3=CC=CC=C3N=C2NC4=CC=CC(C#C)=C4)=C1
• InChI key: SCUPZFSEJFWQIS-UHFFFAOYSA-N

詳細

Biochem/physiol Actions

TD52, an erlotinib analog, is a putative inhibitor of CIP2A that exhibits potent antitumor efficacy on HCC and TNBC cells. TD52 induces apoptosis through downregulation of CIP2A (Cancerous inhibitor of protein phosphatase 2A) in HCC, NSCLC and TNBC cells. Apparently TD52 indirectly downregulates CIP2A transcripts through interrupting the binding of Elk1 to CIP2A promoter. TD52 is a weak inhibitor of EGFR tyrosine kinase.

putative inhibitor of CIP2A that exhibits potent antitumor efficacy on HCC and TNBC cells.

安全性情報

• 保管分類: 11 - Combustible Solids
• WGK: WGK 3