SML1729

SW044248

≥98% (HPLC)

• 別名: 2-(5-Ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-N-(2-methoxyphenyl)butanamide
• 実験式（ヒル表記法）: C₂₂H₂₃N₅O₂S
• CAS番号: 522650-83-5
• 分子量: 421.52
• MDL番号: MFCD03487851
• UNSPSCコード: 12352202
• PubChem Substance ID: 329826043

特性

• アッセイ: ≥98% (HPLC)
• フォーム: powder
• 色: white to beige
• 溶解性: DMSO: 5 mg/mL, clear (warmed)
• 保管温度: 2-8°C
• SMILES記法: CCC(C(NC1=C(OC)C=CC=C1)=O)SC2=NC(N(CC)C3=C4C=CC=C3)=C4N=N2

詳細

生物化学的／生理学的作用

SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2, catalyzed DNA decatenation in a manner distinct from that of camptothecin (Cat. Nos. 208925 & C9911). SW044248 is shown to exhibit antiproliferation efficacy against a subset of non-small-cell lung cancer (NSCLC) cultures (IC₅₀ <5 μM), including HCC4017 (IC₅₀ = 1.68 μM) as a result of DNA damage and apoptosis induction, while exhibiting little potency toward the non-cancerous HBEC30KT lung epithelial cells (IC₅₀ >10 μM) derived from the same patient as HCC4017.

SW044248 is a cell permeable, indolotriazine-based compound that selectively inhibits topoisomerase 1 (Top 1), but not Top 2.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable