SML1383

OG-L002 hydrochloride

≥98% (HPLC)

• 別名: 4′-((1R,2S)-2-Aminocyclopropyl)-[1,1′-biphenyl]-3-ol hydrochloride
• 実験式（ヒル表記法）: C₁₅H₁₅NO · HCl
• CAS番号: 1357299-45-6
• 分子量: 261.75
• UNSPSCコード: 12352200
• PubChem Substance ID: 329825831
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• 形状: powder
• 保管条件: desiccated
• 色: , light yellow to dark orange
• 溶解性: DMSO: 20 mg/mL, clear
• 保管温度: 2-8°C
• SMILES記法: N[C@@H]1[C@@H](C(C=C2)=CC=C2C3=CC=CC(O)=C3)C1.Cl
• InChI: 1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1
• InChI Key: LPVCAMIPTMRRLZ-LIOBNPLQSA-N

詳細

生物化学的／生理学的作用

OG-L002 is a recently developed inhibitor with IC₅₀ of 20 nM at LSD1 and much lower activity at MAO-A and MAO-B (1.38 and 0.72 μM, respectively). OG-L002 exhibits potent anti-viral activity in vitro and in mouse models of HSV infection. Lysine specific demethylase 1 (LSD1) is a histone demethylase that removes methyl groups from lysine 4 or 9 of H3 histone tails. Inhibition of LSD1 leds to suppression of herpes simplex and herpes zoster viral infections and viral reactivation from latency. MAO inhibitors (pargyline, tranylcypromine) are known to inhibit LSD1, but with low potency and selectivity. OG-L002 is a more selective and potent tool for LSD1 inhibition.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable