SBR00088

Rilpivirine

≥95% (HPLC), powder

• 別名: 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile, R 278474, TMC 278
• 実験式（ヒル表記法）: C₂₂H₁₈N₆
• CAS番号: 500287-72-9
• 分子量: 366.42
• MDL番号: MFCD11046372
• UNSPSCコード: 51101500

特性

• 品質水準: 100
• アッセイ: ≥95% (HPLC)
• 形状: powder
• 色: white to yellow, or beige
• 抗生物質活性スペクトル: viruses
• 作用機序: enzyme | inhibits
• 輸送温度: ambient
• 保管温度: −20°C
• SMILES記法: CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
• InChI: 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
• InChI Key: YIBOMRUWOWDFLG-ONEGZZNKSA-N

詳細

詳細

Rilpivirine is an antibiotic which belongs to the class of compounds known as non-nucleoside reverse transcriptase inhibitors (NNRTIs).

生物化学的／生理学的作用

Rilpivirine inhibits the activity of the reverse transcriptase enzyme, which is essential for the replication of HIV-1. Specifically, it binds to a specific site on the enzyme and blocks its activity, thereby preventing the conversion of viral RNA into DNA, which is an essential step for the integration of viral DNA into host cells.

Rilpivirine is a next generation nonnucleoside reverse transcriptase inhibitor (NNRTI), It has been shown to be active against many HIV strains with mutations that confer resistance to the first-generation NNRTIs.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable