SAB6010057

Anti-phospho-ERN1 (S724) antibody, clone 1F12, Rabbit Monoclonal

recombinant, expressed in HEK293F cells

• 別名: Serine/threonine-protein kinase/endoribonuclease IRE1, Endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, Ire1-alpha, IRE1a, Serine/threonine-protein kinase, Endoribonuclease, ERN1
• UNSPSCコード: 12352203

特性

• リコンビナント: expressed in HEK 293 F cells
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品タイプ: primary antibodies
• クローン: 1F12, recombinant monoclonal
• 形状: liquid
• 分子量: 150 kDa
• 精製方法: affinity chromatography
• 化学種の反応性: human
• 濃度: 0.6mg/ml
• テクニック: ELISA: 2000:10000; flow cytometry: 1:50-1:200; immunofluorescence: 1:50-1:200; immunohistochemistry: 1:50-1:200
• アイソタイプ: IgG
• UniProtアクセッション番号: O75460
• 輸送温度: wet ice
• 保管温度: -10 to -25°C
• ターゲットの翻訳後修飾: phosphorylation (pSer724)

詳細

詳細

Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation (PubMed:9637683, PubMed:11175748, PubMed:12637535). The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis (PubMed:24508390).

免疫原

A synthesized peptide derived from human Phospho-ERN1 (S724)

シーケンス

GRH-pS-FSR

物理的形状

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

保管および安定性

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable