SAB5702338

Anti-α-Actinin-4 Antibody, clone 5Y3R6, Rabbit Monoclonal

• 別名: ACTININ-4, FSGS, FSGS1
• UNSPSCコード: 12352203
• NACRES: NA.46

特性

• 由来生物: rabbit
• 品質水準: 100
• 物質: colorless
• クローン: 5Y3R6, monoclonal
• フォーム: liquid
• 分子量: 100 kDa
• 交差性: rat, human, rat
• 濃度: 0.55 mg/mL
• テクニック: immunofluorescence: 1:50 - 1:200; immunoprecipitation (IP): 1:50 - 1:200; western blot: 1:500 - 1:2000
• 色: colorless
• アイソタイプ: IgG
• 免疫原配列: MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPE
• UniProtアクセッション番号: O43707
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ACTN4(81)

詳細

詳細

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

免疫原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human α-Actinin-4 (O43707).

PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

アプリケーション

WB, IF/ICC, IP

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1