由来生物
rat
結合体
FITC conjugate
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
GL-1, monoclonal
フォーム
buffered aqueous solution
交差性
mouse
濃度
0.5 mg/mL
テクニック
flow cytometry: suitable
アイソタイプ
IgG2a
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
2-8°C
遺伝子情報
mouse ... Cd86(12524)
詳細
Cluster of differentiation 86 (CD86), also known as B7-2, is encoded by the gene mapped to human chromosome 3q13.33. CD86 is a co-stimulatory molecule expressed on various immune cells. The encoded protein belongs to the immunoglobulin (Ig) superfamily.
The rat monoclonal antibody GL-1 reacts with CD86 (B7-2), a 70-80 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
免疫原
LPS-activated CBA/Cs mouse splenic B cells
アプリケーション
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
生物化学的／生理学的作用
Cluster of differentiation 86 (CD86) plays a vital role in immune responses. Mutations in the gene leads to the development of pneumonia-induced sepsis by downregulating CD86 gene expression in monocytes. Additionally, genetic variation in the gene increases the risk of susceptibility to colorectal cancer.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
PBS（pH 7.4、15 mM アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
適切な製品が見つかりませんか。
製品選択ツール.をお試しください
保管分類コード
12 - Non Combustible Liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4700562-100UG:
最新バージョンのいずれかを選択してください：
MicroRNA binding site polymorphisms as biomarkers of cancer risk.
Pelletier C and Weidhaas JB
Expert Review of Molecular Diagnostics, 10, 817-829 (2010)
CD86 polymorphism affects pneumonia-induced sepsis by decreasing gene expression in monocytes.
Song H
Inflammation, 38, 879-885 (2015)
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
Chapoval Al
Nature Immunology, 2, 269-274 (2001)
Distinct role of CD86 polymorphisms (rs1129055, rs17281995) in risk of cancer: evidence from a meta-analysis.
Geng P
PLoS ONE, 9 (2014)
Wen-Horng Wang et al.
ImmunoHorizons, 3(7), 254-261 (2019-07-30)
The SYK protein-tyrosine kinase is a well-known mediator of signals elicited by the clustering of BCR complexes and other receptors that bear components that contain one or more ITAM sequences. Additional roles for the kinase in signaling through other receptor
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
製品に関するお問い合わせはこちら（テクニカルサービス）