SAB4502150

Anti-ATP6V1H antibody produced in rabbit

affinity isolated antibody

• 別名: V-ATPase 50/57 kDa subunits, V-ATPase subunit H, VMA13, Vacuolar proton pump subunit H, Vacuolar proton pump subunit SFD
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: antigen 55 kDa
• 化学種の反応性: mouse, human
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:20000; immunohistochemistry: 1:50-1:100
• NCBIアクセッション番号: Q9UI12
• UniProtアクセッション番号: Q9UI12
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... ATP6V1H(51606)

詳細

詳細

The gene ATP6V1H (ATPase H⁺ transporting V₁ subunit H) is mapped to human chromosome 8q11.2. It encodes a lysosomal protein with a molar mass of 50/57kDa. This protein forms the subunit of vacuolar ATPase (V-ATPase), a protein widely found in various eukaryotic endomembrane organelles. V-ATPase is a member of the rotary ATPase family, the members of which use rotary motor mechanisms for the transportation of ions across membranes. V-ATPase has two domains, V₀ and V₁ that function in transportation of proton and hydrolysis of ATP, respectively. The V₁ domain is composed of eight subunits, A-H.

免疫原

The antiserum was produced against synthesized peptide derived from human ATP6V1H.

Immunogen Range: 341-390

生物化学的／生理学的作用

The gene ATP6V1H (ATPase H⁺ transporting V₁ subunit H) encodes the regulatory subunit H of the V₁ domain of V-ATPase. This multisubunit complex of V-ATPase functions in the acidification of intracellular compartments via the energy generated from ATP hydrolysis. Therefore, V-ATPase participates in receptor-mediated endocytosis, intracellular trafficking processes and degradation of proteins. Down-regulation of ATP6V1H gene in human pancreatic islets has been associated with type 2 diabetes. Its expression is negatively associated with HbA1c levels. It has a positive regulatory effect on glucose-stimulated insulin secretion.

特徴および利点

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable