SAB4502131

Anti-RNF138 antibody produced in rabbit

affinity isolated antibody

• 別名: E3 ubiquitin-protein ligase RNF138, NLK-associated RING finger protein, Nemo-like kinase-associated RING finger protein, RING finger protein 138
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen 28 kDa
• 化学種の反応性: human, mouse, rat
• 濃度: ~1 mg/mL
• テクニック: ELISA: 1:20000; western blot: 1:500-1:1000
• NCBIアクセッション番号: Q8WVD3
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... RN138(51444)

詳細

詳細

Anti-RNF138 antibody detects endogenous levels of total RNF138 protein.

The RNF138 (RING (really interesting new gene) finger protein 138) gene is mapped to human chromosome 18q12.1 and is predominantly expressed in testis. It encodes an E3 ubiquitin ligase, which is a CaV2.1 (voltage gated calcium channel) binding protein. It is a 245 amino acid protein containing a RING (really interesting new gene) domain at the N-terminal, zinc fingers, and an ubiquitin interacting motif at the C-terminal.

免疫原

The antiserum was produced against synthesized peptide derived from human RNF138.

Immunogen Range: 31-80

生物化学的／生理学的作用

Upregulation of RNF138 (RING (really interesting new gene) finger protein 138) induces polyubiquitination and increases the synthesis/degradation of CaV2.1 (voltage gated calcium channel). In response to DNA damage, RNF138 is localized to the DNA damage site mediated by zinc fingers. Deletion of RNF138 increases the sensitivity to DNA damaging agents and chromosomal instability. RNF138 is upregulated in gliomas.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: nwg
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable