由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
分子量
antigen 86 kDa
化学種の反応性
mouse, rat, human
濃度
~1 mg/mL
テクニック
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... IKBKB(3551)
詳細
IKBKB codes for the enzyme, inhibitor of nuclear factor kappa B kinase subunit β (IKK-β/I-K-B kinase 2). It is mapped to human chromosome 8p11.
免疫原
The antiserum was produced against synthesized peptide derived from human IKK-beta.
Immunogen Range: 166-215
Immunogen Range: 166-215
アプリケーション
Anti-IKK-β antibody produced in rabbit has been used in western blotting.
生物化学的／生理学的作用
Inhibitor of nuclear factor kappa B kinase subunit β (IKK-β) acts as a regulator of cell survival and inflammatory response. It promotes cell survival and metabolic adaptation during glutamine deprivation. IKK-β phosphorylates inhibitor of KB proteins and facilitates their degradation. This further leads to the activation of nuclear factor KB (NF-KB) transcription factors. It also phosphorylates β-catenin, tuberous sclerosis 1 (TSC1) and Bcl-2-associated death promoter (BAD).
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
物理的形状
ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
12 - Non Combustible Liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Adrenomedullin inhibits osteoclast differentiation through the suppression of receptor activator of nuclear factor-KB ligand-induced nuclear factor-KB activation in glucocorticoid-induced osteoporosis.
Liu Y, et al.
Experimental and Therapeutic Medicine, 14(5), 4009-4016 (2017)
IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
Michael A. R, et al.
Genes & Development, 30(16), 1837- 1851 (2016)
Deficiency of innate and acquired immunity caused by an IKBKB mutation.
Pannicke U, et al.
The New England Journal of Medicine, 369(26), 2504-2514 (2013)
Canonical nuclear factor KB pathway links tumorigenesis of synchronous mantle-cell lymphoma, clear-cell renal-cell carcinoma, and GI stromal tumor.
Guo R, et al.
Journal of Clinical Oncology, 29(10), e257-e261 (2011)
Yuanxin Liu et al.
Experimental and therapeutic medicine, 14(5), 4009-4016 (2017-10-27)
The current study aimed to improve the understanding on the association between adrenomedullin and osteoporosis in mice with glucocorticoid-induced osteoporosis. Bone resorption and osteoporosis-associated indexes, including maximum load, stiffness, energy to failure, ultimate strength, elastic modulus, post-yield displacement and post-yield
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