SAB4301310

Anti-phospho-PEK/PERK (pThr⁹⁸¹) antibody produced in rabbit

affinity isolated antibody

• 別名: PEK, PERK
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: 125 kDa
• 化学種の反応性: human
• 濃度: 1.0 mg/mL
• テクニック: immunohistochemistry: 1:50-1:100
• アイソタイプ: IgG
• アクセッション番号: NP_004827.4.
• UniProtアクセッション番号: Q9NZJ5
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr981)
• 遺伝子情報: human ... EIF2AK3(9451)

詳細

詳細

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)/EIF2AK3 (eukaryotic translation initiation factor 2 α kinase 3) is a type I transmembrane protein, located on ER (endoplasmic reticulum). It is a member of the eIF2α kinase subfamily. This gene is located on human chromosome 2p. EIF2AK3 has 16 exons and is made of cytoplasmic and kinase domains.

特異性

The antibody detects endogenous levels of PEK/PERK only when phosphorylated at threonine 981.

免疫原

Peptide sequence around phosphorylation site of threonine 981(A-R-H(p)-T-G) derived from Human PEK/PERK.

生物化学的／生理学的作用

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) helps to detect the protein-folding imbalance created by endoplasmic reticulum (ER) stress. EIF2AK3 works as an endoplasmic reticulum (ER) stress sensor to modulate global protein synthesis. Mutation in EIF2AK3 gene results in Wolcott-rallison syndrome.

特徴および利点

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物理的形状

ウサギIgGのPBS溶液（Mg2+およびCa2+を含まず）、pH 7.4、150 mM NaCl、0.02％ アジ化ナトリウム、50％ グリセロール

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable