SAB4300470

Anti-CTNNB1 (Ab-33) antibody produced in rabbit

affinity isolated antibody

• 別名: 抗CTNNB抗体 ウサギ宿主抗体, 抗DKFZp686D02253抗体 ウサギ宿主抗体, 抗FLJ25606抗体 ウサギ宿主抗体, 抗FLJ37923抗体 ウサギ宿主抗体
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~92 kDa
• 化学種の反応性: human, rat, mouse
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (L-D-S-G-I)
• NCBIアクセッション番号: NP_001091679.1
• UniProtアクセッション番号: P35222
• アプリケーション: research pathology
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... CTNNB1(1499)

詳細

詳細

Catenin beta-1 (CTNNB1) encoding β-catenin, belongs to armadillo-repeat family. In human chromosome, the gene CTNNB1 is localized on 3p22.1.

免疫原

Peptide sequence around aa. 31-35 (L-D-S-G-I), according to the protein CTNNB1.

生物化学的／生理学的作用

Catenin beta-1 (CTNNB1) is a signalling molecule in the nucleus and anchors actin cytoskeleton to cadherin-based adherens junctions. Phosphorylation causes dissociation of β-catenin from E-cadherin and degradation by proteasome pathway. β-catenin is a key molecule in wingless/integrated (wnt) signalling. β-catenin forms a complex with kindlin 2 and T-cell factor 4 (TCF4) to regulate wnt target gene expression. Mutations in adenomatous polyposis coli (APC) and CTNNB1 gene affects β-catenin intracellular localization and stability, contributing to aberrant expression of wnt/β-catenin in malignant melanoma. β-catenin is a major oncoprotein, which downregulates death associated protein kinase 2 (Dapk2) and inhibits anoikis of cancer cells. β-catenin expression is suppressed and its downstream gene transcription function is regulated by a tumor suppressor protein fragile histidine triad (Fhit). High expression of mucin 1 (MUC1), translocates β-catenin out of the nucleus and inhibits β-catenin regulated cell proliferation. Somatic mutations of CTNNB1 in glycogen synthase kinase 3β−casein kinase 1 (GSK-3β−CK1) phosphorylation site results in loss of phosphorylation of β-catenin. This causes aberrant wnt-signalling and leads to adrenocortical adenomas and adrenocortical carcinoma.

特徴および利点

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ターゲットの説明

Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable