SAB4300204

Anti-phospho-SNCA (pTyr¹²⁵) antibody produced in rabbit

affinity isolated antibody

• 別名: 抗MGC110988抗体 ウサギ宿主抗体, 抗NACP抗体 ウサギ宿主抗体, 抗PARK1抗体 ウサギ宿主抗体, 抗PARK4抗体 ウサギ宿主抗体
• MDL番号: MFCD02095740
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~18 kDa
• 化学種の反応性: human
• 濃度: 1 mg/mL
• テクニック: indirect immunofluorescence: 1:100-1:200; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (E-A-YP-E-M)
• NCBIアクセッション番号: NP_000336.1
• UniProtアクセッション番号: P37840
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pTyr125)
• 遺伝子情報: human ... SNCA(6622)

詳細

免疫原

Peptide sequence around phosphorylation site of tyrosine 125 (E-A-Y(p)-E-M), according to the protein SNCA.

特徴および利点

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ターゲットの説明

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable