SAB4300200

Anti-phospho-MAPK14 (pThr¹⁸⁰) antibody produced in rabbit

affinity isolated antibody

• 別名: Anti-CSBP1 antibody produced in rabbit, Anti-CSBP2 antibody produced in rabbit, Anti-CSPB1 antibody produced in rabbit, Anti-EXIP antibody produced in rabbit, Anti-mitogen-activated protein kinase 14 antibody produced in rabbit
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 分子量: ~43 kDa
• 化学種の反応性: rat, human, mouse
• 濃度: 1 mg/mL
• テクニック: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• アイソタイプ: IgG
• 免疫原配列: (E-M-TP-G-Y)
• NCBIアクセッション番号: NP_001306.1
• UniProtアクセッション番号: Q16539
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: phosphorylation (pThr180)
• 遺伝子情報: human ... MAPK14(1432)

詳細

免疫原

Peptide sequence around phosphorylation site of threonine 180 (E-M-T(p)-G-Y ), according to the protein MAPK14.

特徴および利点

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ターゲットの説明

Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.

物理的形状

PBS（0.02％ アジ化ナトリウム、50％ グリセロール含有）

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable