由来生物
mouse
抗体製品の状態
purified immunoglobulin
抗体製品タイプ
primary antibodies
クローン
3F12, monoclonal
形状
buffered aqueous solution
分子量
antigen ~53 kDa
化学種の反応性
human, bovine, monkey
濃度
~1 mg/mL
テクニック
immunoblotting: 0.5-1 μg/mL using using whole extracts of HeLa cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.
アイソタイプ
IgG1
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TOM1L1(10040)
詳細
The gene TOM1L1 (target of myb1 like 1 membrane trafficking) is mapped to human chromosome 17q23. The protein has a VHS (Vps27p/Hrs/Stam) domain at the N-terminal, a GAT (GGA (Golgi-localizing, γ-adaptin ear domain homology, ADP-ribosylation factor (Arf)-binding protein and Tom) domain at the center and interaction motifs at the C-terminal.
免疫原
immunized with a TOM1L1 fusion protein.
生物化学的／生理学的作用
TOM1L1 (target of myb1 like 1 membrane trafficking) is an adaptor protein, which is involved in vesicular trafficking as well as intracellular signaling. It negatively controls the mitogenic and transforming functions in fibroblasts by working as a substrate for SRC (tyrosine protein kinase). It is involved in EGF (epidermal growth factor)-mediated internalization of EGF receptor. TOM1L1 is downregulated in cutaneous squamous cell carcinoma and esophageal squamous cell carcinoma.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200652-BULK:
SAB4200652-100UL:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Béatrice Orsetti et al.
Cancer research, 64(18), 6453-6460 (2004-09-18)
Chromosome 17 is severely rearranged in breast cancer. Whereas the short arm undergoes frequent losses, the long arm harbors complex combinations of gains and losses. In this work we present a comprehensive study of quantitative anomalies at chromosome 17 by
Yu Qi et al.
Anticancer research, 30(9), 3535-3539 (2010-10-15)
Src-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm
Ahmed Elmarghani et al.
Mediators of inflammation, 2009, 416298-416298 (2010-02-26)
TOM1L (target of Myb-1 Like) was identified as a binding partner for the full length and catalytically-active Lck in a yeast 2-hybrid screening assay. Here we show that in Jurkat T cells stimulated by CD3/CD28 coligation where the expression of
Ning Sheng Liu et al.
The EMBO journal, 28(22), 3485-3499 (2009-10-03)
Although many proteins have been shown to participate in ligand-stimulated endocytosis of EGF receptor (EGFR), the adaptor protein responsible for interaction of activated EGFR with endocytic machinery remains elusive. We show here that EGF stimulates transient tyrosine phosphorylation of Tom1L1
Audrey Sirvent et al.
Molecular & cellular proteomics : MCP, 11(12), 1937-1950 (2012-10-02)
The non-receptor tyrosine kinase SRC is frequently deregulated in human colorectal cancer (CRC), and SRC increased activity has been associated with poor clinical outcomes. In nude mice engrafted with human CRC cells, SRC over-expression favors tumor growth and is accompanied
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