SAB4200439

Anti-EXOSC5 (N-terminal) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: Anti-Exosome component 5, p12B, Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-hRrp46p
• UNSPSCコード: 12352203

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: antigen ~25 kDa
• 交差性: human
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): 1-2 μg using lysates of human HeLa cells.; indirect immunofluorescence: 1-2 μg/mL using human HeLa cells.; western blot: 1-2 μg/mL using whole extracts of human HEK-293T cells.
• UniProtアクセッション番号: Q9NQT4
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... EXOSC5(56915)

詳細

詳細

Exosome component 5 (EXOSC5) protein is a non-catalytic element of the RNA exosome complex in eukaryotes. The EXOSC5 gene is located on the human chromosome at 19q13.2.

特異性

Anti-EXOSC5 (N-terminal) recognizes human EXOSC5.

免疫原

peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.

アプリケーション

Anti-EXOSC5 (N-terminal) antibody produced in rabbit may be used in:

• immunoblotting
• immunoprecipitation
• immunofluorescence

生物化学的／生理学的作用

Exosome component 5 (EXOSC5) plays a role in the processing and degradation of RNA. This protein also plays a role in cleaving the DNA during apoptosis. EXOSC5 possesses a 3′-5′ exoribonuclease activity. Overexpression of the EXOSC5 gene is associated with several cancers such as melanoma, prostate, colorectal and lung cancer.

物理的形状

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2-8°C for up to one month. Forextended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable