由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~95 kDa
交差性
human
濃度
~1.0 mg/mL
テクニック
western blot: 0.5-1.0 μg/mL using lysates of HEK-293Tcells overexpressing human PIWIL4.
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PIWIL4(143689)
詳細
P-element Induced WImpy testis (PIWI)-like 4 (PIWIL4) protein belongs to the PIWI subfamily. This protein is localized in tumorous colon tissues. PIWIL4 gene is located on the human chromosome at 11q21.
特異性
Anti-PIWIL4 recognizes human PIWIL4.
免疫原
peptide corresponding to an internal region of human PIWIL4, conjugated to KLH. The corresponding sequence differs by a single amino acid in mouse and rat.
アプリケーション
Anti-PIWIL4 antibody produced in rabbit may be used in immunoblotting.
生物化学的／生理学的作用
P-element Induced WImpy testis (PIWI)-like 4 (PIWIL4) protein promotes tumorigenesis and cell invasion. It is expressed in several cancers like colon and breast cancer. This protein enhances cell growth and blocks apoptosis in cervical cancer cells. PIWIL4 protein is also involved in the chromatin-modifying pathway of human somatic cells. Mutation in the PIWIL4 gene is associated with breast cancer.
物理的形状
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
保管および安定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB4200429-VAR:
SAB4200429-BULK:
SAB4200429-200UL:
最新バージョンのいずれかを選択してください：
Chang Su et al.
FEBS letters, 586(9), 1356-1362 (2012-04-10)
Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of cancer worldwide. The relationship between PIWIL4 and cervical cancer is still unknown. Here, we found that PIWIL4 is up-regulated
Kaipeng Xie et al.
Journal of ovarian research, 12(1), 1-1 (2019-01-06)
Ovarian cancer remains the most fatal gynecologic malignancy worldwide due to delayed diagnosis as well as recurrence and drug resistance. Thus, the development of new tumor-related molecules with high sensitivity and specificity to replace or supplement existing tools is urgently
Keiki Sugimoto et al.
Biochemical and biophysical research communications, 359(3), 497-502 (2007-06-05)
The field of epigenetics has made progress by the identification of the small RNA-mediated epigenetic modification. However, little is known about the key proteins. Here, we report that the human PIWI-like family is a candidate protein that is involved in
Zifeng Wang et al.
The Journal of biological chemistry, 291(20), 10646-10658 (2016-03-10)
P-element-induced wimpy testis (PIWI) proteins bind to PIWI-interacting RNAs and play key roles in the biogenesis and functions of PIWI-interacting RNAs. It has been reported that PIWI proteins are essential for stem cell self-renewal and germline development in diverse organisms
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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