SAB4200282

Anti-TRIM2 (C-terminal region) antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

• 別名: Anti-Tripartite motif-containing protein 2, RNF86, Narf
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: buffered aqueous solution
• 化学種の反応性: rat, human
• 強化検証: recombinant expression; Learn more about Antibody Enhanced Validation
• 濃度: ~1.0 mg/mL
• テクニック: immunoprecipitation (IP): 5-10 μg using rat spinal cord extracts (S1 fraction); western blot: 1.5-3.0 μg/mL using MCF7 cell lysates
• UniProtアクセッション番号: Q9C040
• 輸送温度: dry ice
• 保管温度: −20°C
• 遺伝子情報: human ... TRIM2(23321) ; rat ... Trim2(361970)

詳細

詳細

Tripartite motif containing 2 (TRIM2) is an E3 ubiquitin ligase, encoded by the gene mapped to human chromosome 4q31.3. The encoded protein belongs to the TRIM– NCL-1, HT2A and Lin-41 (NHL) protein family. This 81kDa protein is characterized with an N-terminal really interesting new gene (RING) finger domain and a B-box domain, a middle coiled-coil domain and a C-terminal NHL domain.

免疫原

synthetic peptide corresponding to a sequence located near the C-terminus of human TRIM2, conjugated to KLH. The corresponding sequence is identical in mouse and rat TRIM2.

生物化学的／生理学的作用

Tripartite motif containing 2 (TRIM2) ubiquitinates neurofilament light chain, B-cell lymphoma 2 (Bcl-2)-interacting mediator and motor protein myosin V. ) It has a role in polarization of neurons and outgrowth of axons. Loss of function of the protein has been linked to early-onset axonal neuropathy.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable