由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
分子量
antigen ~30 kDa
交差性
human
包装
antibody small pack of 25 μL
濃度
~1.0 mg/mL
テクニック
western blot: 1-2 μg/mL using Whole extracts of HEK-293T cells overexpressing human CPSF4.
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... CPSF4(10898)
mouse ... CPSF4(54188)
rat ... CPSF4(304277)
詳細
Cleavage polyadenylation specificity factor 4 (CPSF4), also called CPSF 30 is a component of the CPSF complex. It comprises of five CCCH zinc finger motifs (ZF1-ZF5). CPSF4 gene is mapped to human chromosome 7q22.1.
特異性
Anti-CPSF4 recognizes human CPSF4.
アプリケーション
Anti-CPSF4 antibody produced in rabbit has been used in chromatin immunoprecipitation and immunoblotting.
生物化学的／生理学的作用
Cleavage polyadenylation specificity factor 4 (CPSF4) is a component of 3′-end mRNA processing machinery and binds to poly(U) sequence of RNA via the zinc finger motifs. These motifs are also involved in protein-protein interactions. CPSF4 along with other proteins primarily coordinate both cleavage and polyadenylation. Their interaction with the non-structural protein 1 (NS1) protein of the influenza virus leads to inhibition of polyadenylation event and 3′ end cleavage of pre-mRNA associated with the host. Elevated expression of CPSF4 is observed in lung adenocarcinomas.
物理的形状
0.01 M PBS溶液(pH 7.4, 15 mMアジ化ナトリウム含有)。
保管および安定性
For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
IXO14874:
SAB4200170-25UL:
SAB4200170-BULK:
SAB4200170-VAR:
SAB4200170-200UL:
最新バージョンのいずれかを選択してください：
Upregulation of cleavage and polyadenylation specific factor 4 in lung adenocarcinoma and its critical role for cancer cell survival and proliferation
Chen W, et al.
PLoS ONE, 8(12), e82728-e82728 (2013)
Jennelle C Hodge et al.
Genes, chromosomes & cancer, 48(10), 865-885 (2009-07-16)
Uterine leiomyomata (UL), the most common neoplasm in reproductive-age women, have recurrent cytogenetic abnormalities including interstitial deletion of 7q. To develop a molecular signature, matched del(7q) and non-del(7q) tumors identified by FISH or karyotyping from 11 women were profiled with
Lee Davidson et al.
Genes & development, 28(4), 342-356 (2014-01-31)
3' end formation of pre-mRNAs is coupled to their transcription via the C-terminal domain (CTD) of RNA polymerase II (Pol II). Nearly all protein-coding transcripts are matured by cleavage and polyadenylation (CPA), which is frequently misregulated in disease. Understanding how
3? end formation of pre-mRNA and phosphorylation of Ser2 on the RNA polymerase II CTD are reciprocally coupled in human cells
Davidson L, et al.
Genes & Development, 28(4), 342-356 (2014)
C R Mandel et al.
Cellular and molecular life sciences : CMLS, 65(7-8), 1099-1122 (2007-12-26)
Most eukaryotic mRNA precursors (premRNAs) must undergo extensive processing, including cleavage and polyadenylation at the 3'-end. Processing at the 3'-end is controlled by sequence elements in the pre-mRNA (cis elements) as well as protein factors. Despite the seeming biochemical simplicity
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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