由来生物
rabbit
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
分子量
18 kDa
交差性
mouse, human
濃度
1 mg/mL
テクニック
ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
遺伝子情報
human ... VKORC1(79001)
詳細
Vitamin K epoxide reductase complex subunit 1 (VKORC1), also known as vitamin K clotting factor deficiency type 2 (VKCFD2), is an integral, 163-amino acid long transmembrane protein. It is encoded by the gene mapped to a 20Mb region on human chromosome 16p12–q21. VKORC1 is widely expressed in various tissues and organs.
免疫原
Antibody was raised against a 15 amino acid peptide near the amino terminus of human VKORC1.
生物化学的／生理学的作用
Vitamin K epoxide reductase complex subunit 1 (VKORC1) enzyme plays a vital role in vitamin K cycle. It catalyzes the conversion of inactive vitamin K to vitamin K hydroquinone, which is crucial for the post-translational γ-carboxylation of vitamin K–dependent clotting factors II (prothrombin), VII, IX, and X. VKORC1 acts as a key target for oral anticoagulants and is also involved in drug metabolism.{4} Genetic variation in the gene leads to warfarin resistance and multiple coagulation factor deficiency type 2.
特徴および利点
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
関連事項
The action of this antibody can be blocked using blocking peptide SBP3500661.
物理的形状
1 mg/mLのPBS溶液（0.02％アジ化ナトリウム含有）
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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関連製品
保管分類コード
12 - Non Combustible Liquids
引火点(°F)
Not applicable
引火点(℃)
Not applicable
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
SAB3500661-100UG:
最新バージョンのいずれかを選択してください：
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S
Nature (2004)
VKCFD2 - from clinical phenotype to molecular mechanism.
Czogalla KJ
Hamostaseologie (2016)
High prevalence of VKORC1*3 (G9041A) genetic polymorphism in north Indians: A study on patients with cardiac disorders on acenocoumarol.
Sehgal T
Drug Discoveries & Therapeutics (2015)
G-1639A but Not C1173T VKORC1 Gene Polymorphism Is Related to Ischemic Stroke and Its Various Risk Factors in Ukrainian Population.
Dubovyk YI
BioMed Research International (2016)
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