由来生物
rabbit
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
交差性
rat, human, mouse
テクニック
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... WDR74(54663)
詳細
WD repeat domain 74 (WDR74), also known as NOP seven-associated protein 1 (NSA1), is encoded by the gene mapped to human chromosome 11q12.3. The encoded protein is mainly localized in the nucleus and it contains six WD40 repeats.
免疫原
NSA1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human NSA1.
生物化学的/生理学的作用
WD repeat domain 74 (WDR74) along with the nucleolar AAA-ATPase NVL2, plays a vital role in an early cleavage of the pre-rRNA processing pathway. It is also implicated in various biological processes, including cell cycle control and apoptosis. In mouse, this protein plays an essential role in RNA transcription, processing and/or stability during preimplantation development.
特徴および利点
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関連事項
The action of this antibody can be blocked using blocking peptide SBP3500152.
物理的形状
PBS(0.02% アジ化ナトリウム含有)
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関連製品
保管分類コード
10 - Combustible liquids
WGK
WGK 2
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください:
Wdr74 Is Required for Blastocyst Formation in the Mouse
Maserati M, et al.
PLoS ONE, 6(7), e22516-e22516 (2011)
Genes Involved in Human Ribosome Biogenesis are Transcriptionally Upregulated in Colorectal Cancer
Mansilla F, et al.
Scholarly Research Exchange (2009)
Genome-wide analysis of non-coding regulatory mutations in cancer
Weinhold N, et al.
Nature Genetics, 46(11), 1160-1160 (2014)
WDR74 participates in an early cleavage of the pre-rRNA processing pathway in cooperation with the nucleolar AAA-ATPase NVL2.
Hiraishi N, et al.
Biochemical and Biophysical Research Communications, 495(1), 116-123 (2018)
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