SAB3500093

Anti-JMJD1A antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• 別名: Anti-JHDM2A, Anti-JHMD2A, Anti-KDM3A, Anti-Lysine-specific demethylase 3A, Anti-TSGA
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• フォーム: buffered aqueous solution
• 分子量: predicted mol wt 145 kDa
• 交差性: human, mouse, rat
• テクニック: immunofluorescence: suitable; immunohistochemistry: suitable; indirect ELISA: suitable; western blot: suitable
• NCBIアクセッション番号: NP_060903
• UniProtアクセッション番号: Q9Y4C1
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KDM3A(55818)

詳細

詳細

The jumonji domain containing 1A protein (JMJD1A) was originally discovered as a testes specific gene, but has been found to be expressed in numerous tissues. At least two isoforms of JMJD1A are known to exist. This antibody will not cross-react with JMJD1B or JMJD1C.

免疫原

JMJD1A antibody was raised against a 16 amino acid peptide from near the amino terminus of human JMJD1A.

生物化学的／生理学的作用

Jumonji domain containing 1A protein (JMJD1A) is a histone demethylase and specifically demethylates mono- and dimethyl-H3K9. It has also been found to be a novel interaction partner with ER71, a transcription factor expressed in the testes of adult mice and during embryogenesis. JMJD1A is also a downstream gene of signal transducer and activator of transcription 3 (STAT3), a protein that has been found to be important in the maintenance of mouse embryonic stem (mES) cells. Decreased JMJD1A expression is correlated with the differentiation of cultured mES cells following the removal of the cytokine leukemia inhibitory factor (LIF). These findings suggest that JMJD1A might be a signaling molecule having a role in maintaining pluripotency in embryonic stem cells.

特徴および利点

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関連事項

The action of this antibody can be blocked using blocking peptide SBP3500093.

物理的形状

約1 mg/mLのPBS (0.02％ アジ化ナトリウム含有)

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable