SAB1403333

Monoclonal Anti-TNRC6C antibody produced in mouse

clone 3G11, purified immunoglobulin, buffered aqueous solution

• 別名: FLJ20015, KIAA1582
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: mouse
• 結合体: unconjugated
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: 3G11, monoclonal
• 形状: buffered aqueous solution
• 分子量: antigen ~36.89 kDa
• 化学種の反応性: human
• テクニック: immunofluorescence: suitable; indirect ELISA: suitable
• アイソタイプ: IgG2aκ
• NCBIアクセッション番号: NM_018996
• UniProtアクセッション番号: Q9HCJ0
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TNRC6C(57690)

詳細

詳細

Mouse monoclonal antibody raised against a partial recombinant TNRC6C.

TNRC6C (Trinucleotide repeat containing 6C) is a member of GW182 (Gly-Trp) family consisting of a domain similar to Drosophila GW182 (also known as Gawky), a domain rich in GW or WG repeats followed by a glutamine (Q)-rich region at the N-proximal end, a central ubiquitin-associated (UBA) domain and an RNA-binding domain termed as RRM.

免疫原

TNRC6C (NP_061869, 181 a.a. ~ 280 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
TDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAK

アプリケーション

Monoclonal Anti-TNRC6C antibody produced mouse is suitable for indirect ELISA.

生物化学的／生理学的作用

TNRC6C (Trinucleotide repeat containing 6C) plays an important role in the microRNA repression during protein synthesis via miRNA pathway. The C-terminal RRM RNA-binding domain mediates the process of translational repression. Its GW-rich and Q-rich domain also suppress the expression for protein synthesis by binding to a reporter mRNA. In addition to translational repression, the members of the GW182 family, also participate in the deadenylation and decay of miRNA by interacting with argonaute proteins.

物理的形状

無色透明のPBS溶液、pH 7.4

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable