由来生物
rabbit
結合体
unconjugated
抗体製品の状態
IgG fraction of antiserum
抗体製品タイプ
primary antibodies
クローン
polyclonal
フォーム
buffered aqueous solution
化学種の反応性
human
テクニック
immunohistochemistry: 1:50-1:100
indirect ELISA: 1:1000
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
dry ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... TRRAP(8295)
詳細
TRRAP, a member of the TRA1 subfamily of the PI3/PI4 kinase family, is an adapter protein found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. It plays a central role in MYC (c-Myc) transcription activation, and also participates in cell transformation by MYC. TRRAP is required for p53/TP53-, E2F1- and E2F4-mediated transcription activation, and is also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. It likely performs by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Although probably not required in the steps following histone acetylation in processes of transcription activation, it may be required for the mitotic checkpoint and normal cell cycle progression. It is a component of various HAT complexes, including the PCAF, TFTC, TIP60 STAGA and BAF53 complexes. The PI3K/PI4K domain of this nuclear protein is required for the recruitment of HAT complexes, and the MYC-dependent transactivation. Although it is strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, and lacks such activity.
免疫原
TRRAP (Q9Y6H4, 3804-3840)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human TRRAP.
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human TRRAP.
物理的形状
精製済みポリクローナル抗体のPBS溶液（0.09％（W/V）アジ化ナトリウム含有）
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保管分類コード
10 - Combustible liquids
WGK
nwg
引火点(°F)
Not applicable
引火点(℃)
Not applicable
最新バージョンのいずれかを選択してください：
Dilraj Lama et al.
Nature communications, 15(1), 1865-1865 (2024-03-01)
The c-MYC oncogene is activated in over 70% of all human cancers. The intrinsic disorder of the c-MYC transcription factor facilitates molecular interactions that regulate numerous biological pathways, but severely limits efforts to target its function for cancer therapy. Here
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