アッセイ
≥98% (HPLC)
形状
solid
保管条件
protect from light
under inert gas
色
yellow
溶解性
DMSO: ~13 mg/mL
H2O: insoluble
保管温度
−20°C
SMILES記法
Cc1sc(N)c(c1C)C(=O)c2cccc(c2)C(F)(F)F
InChI
1S/C14H12F3NOS/c1-7-8(2)20-13(18)11(7)12(19)9-4-3-5-10(6-9)14(15,16)17/h3-6H,18H2,1-2H3
InChI Key
KKDKAWKYGCUOGR-UHFFFAOYSA-N
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生物化学的／生理学的作用
Allosteric enhancer of A1 adenosine receptors
保管分類コード
13 - Non Combustible Solids
WGK
WGK 3
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, type N95 (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
P1123-50MG:
P1123-10MG:
P1123-VAR:
P1123-BULK:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
D M Dennis et al.
Circulation, 94(10), 2551-2559 (1996-11-15)
There has been increasing interest in the development of agents that utilize endogenous adenosine to exert their actions. We tested the hypothesis that substances that either potentiate the activity (allosteric enhancers) or increase the interstitial concentration (inhibitors of metabolism) of
Daniele Pietra et al.
Journal of theoretical biology, 267(4), 663-675 (2010-08-31)
A new mathematical model, referred to as Enhancer and Competitive Allosteric Modulator (ECAM) model, developed with the aim of quantitatively describing the interaction of an allosteric modulator with both enhancer and competitive properties towards G-protein-coupled receptors is described here. Model
Jianzhong Shen et al.
Circulation research, 96(9), 982-990 (2005-04-16)
Adenosine is a vascular endothelial cell mitogen, but anti-mitogenic for aortic smooth muscle cells and fibroblasts when acting via the A2B adenosine receptor. However, we show that adenosine increases porcine coronary artery smooth muscle cell (CASMC) number, cellular DNA content
B Musser et al.
The Journal of pharmacology and experimental therapeutics, 288(2), 446-454 (1999-01-26)
The 2-amino-3-benzoylthiophene PD 81,723 has been shown to exhibit allosteric enhancement of adenosine A1 receptor binding and function. The aim of this study was to clarify the mechanism of this effect using membranes purified from rat brain and Chinese hamster
M C Peeters et al.
Biochemical pharmacology, 84(1), 76-87 (2012-03-28)
The adenosine A1 receptor is a member of the large membrane protein family that signals through G proteins, the G protein-coupled receptors (GPCRs). GPCRs consist of seven transmembrane domains connected by three intracellular and three extracellular loops. Their N-terminus is
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