P0999

抗カリウムチャネルK_v10.1(EAG-1)抗体 ウサギ宿主抗体

affinity isolated antibody, lyophilized powder

• 別名: 抗Ether-a-go-go K⁺チャネル1抗体, 抗KCNH1抗体
• MDL番号: MFCD08705506
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 200
• 結合体: unconjugated
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 形状: lyophilized powder
• 化学種の反応性: human, mouse, rat
• テクニック: western blot: 1:200 using rat brain lysate and transfected cells HEK-K_V10.1.
• UniProtアクセッション番号: O95259
• 輸送温度: wet ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... KCNH1(3756) ; mouse ... Kcnh1(16510) ; rat ... Kcnh1(65198)

詳細

詳細

Human genome codes for 40 voltage-gated K⁺ channels (K_V). Voltage-gated-like ion channels (VGICs) are the third largest group of signaling molecules found in humans. K⁺ channels can be divided into four structural types based on their number of transmembrane regions and mode of activation, namely K_ir- the inwardly rectifying 2-transmembrane K⁺ channels, K_2P- 2-pore 4-transmembrane K⁺ channels, K_Ca- Ca²⁺-activated 6-transmembrane or 7-transmembrane K⁺ channels, and K_V- voltage-gated 6-transmembrane K⁺ channels. KCNH1 (potassium voltage-gated channel H1) is a K_V channel and is also known as K_V10.1. Like all K_V members, it is composed of four α-subunits with each containing six transmembrane α-helical segments, and a membrane-re-entering P-loop. These surround a central pore as homotetramers or heterotetramers. KCNH1 mRNA and protein are both abundantly found in the brain, though its peripheral tissue expression is restricted. This gene is localized to human chromosome 1q32.1.

特異性

K_V10.1に特異的であり、K_V10.2との交差反応はありません。

免疫原

ラットK_V10.1のアミノ酸残基802-817に相当するペプチド(GDPAKRKGWARFKDAC)。この配列はマウスと同一であり、ヒトと14/16残基一致しています。

生物化学的／生理学的作用

KCNH1 (potassium voltage-gated channel H1) initiates a slowly activating, non-inactivating K₊ current in a heterologous system. In skeletal muscles, it is expressed only during the phase when myoblasts exit the cell cycle and fuse, and thus, it plays an essential role in skeletal muscle development. This protein is found to be expressed in ∼70% human cancers, including gastric, mammary tumors, colon carcinoma, and sarcomas. This channel is implicated in neuronal disorders such as Zimmermann-Laband and Temple-Baraitser syndromes.

ターゲットの説明

Potassium Channel K_v10.1 (EAG-1) encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming α-subunit of a voltage-gated non-inactivating delayed rectifier potassium channel.

物理的形状

Lyophilized from phosphate buffered saline containing 1% bovine serum albumin and 0.05% sodium azide.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable