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P0248

PNU-37883A

Name: PNU-37883A
Brand: SIGMA

≥98% (HPLC), powder

別名:

N-(1-アダマンチル)-N'-シクロヘキシル-4-モルホリンカルボキサミジン塩酸塩

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About This Item

実験式（ヒル表記法）:

C₂₁H₃₆ClN₃O

CAS番号:

57568-80-6

分子量:

381.98

MDL番号:

MFCD06798347

UNSPSCコード:

12352200

PubChem Substance ID:

24277692

アッセイ

≥98% (HPLC)

形状

powder

色

white

溶解性

DMSO: ~23 mg/mL
H₂O: insoluble

保管温度

2-8°C

SMILES記法

Cl.C1CCC(CC1)\N=C(/NC23CC4CC(CC(C4)C2)C3)N5CCOCC5

遺伝子情報

human ... KCNJ8(3764)

生物化学的／生理学的作用

Selective inhibitor of K_ir6.1/SUR2B channels.

保管分類コード

13 - Non Combustible Solids

WGK

WGK 3

引火点(°F)

Not applicable

引火点(℃)

Not applicable

個人用保護具 (PPE)

Eyeshields, Gloves, type N95 (US)

試験成績書（COA）

製品のロット番号・バッチ番号を入力して、試験成績書（COA）を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。

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Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A.

H Kovalev et al.

British journal of pharmacology, 141(5), 867-873 (2004-02-06)

1. In this study, we have used Kir6.1/Kir6.2 chimeric proteins and current recordings to investigate the molecular basis of PNU-37883A inhibition of cloned K(ATP) channels. 2. Rat Kir6.1, Kir6.2 and Kir6.1/Kir6.2 chimeras were co-expressed with either SUR2B or SUR1, following

Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat.

Bobby D Nossaman et al.

Journal of cardiovascular pharmacology, 50(4), 358-366 (2007-12-01)

The free radical peroxynitrite (ONOO-) is formed in biological systems from the reaction of nitric oxide (NO) with superoxide (O2-) and can react with protein and nonprotein thiol groups to produce tissue injury. However, these pathologic actions of (ONOO-) may

Potassium-induced increase in renal kallikrein secretion is attenuated in dissected renal connecting tubules of young spontaneously hypertensive rats.

Mariko Yamanaka et al.

International immunopharmacology, 2(13-14), 1957-1964 (2002-12-20)

It is suggested that attenuation of the renal kallikrein-kinin system (KKS) involved the development of hypertension in young spontaneously hypertensive rats (SHR). In the present study, a comparison was made between young SHR and Wistar Kyoto rats (WKY) to examine

Interaction of acetylcholine with Kir6.1 channels heterologously expressed in human embryonic kidney cells.

Salma Toma Hanna et al.

European journal of pharmacology, 515(1-3), 34-42 (2005-05-17)

Kir6.1 subunit is one of the pore-forming components of K(ATP) channel complex. The endogenous modulation of Kir6.1 subunit function has been largely unknown. Whether acetylcholine modulated the function of Kir6.1 subunit stably expressed in human embryonic kidney (HEK-293) cells was

Effects of U-37883A on intracellular Ca2+ -activated large-conductance K+ channels in pig proximal urethral myocytes.

Noriyoshi Teramoto et al.

European journal of pharmacology, 506(1), 1-7 (2004-12-14)

Kinetic studies of U-37883A (4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexyl-hydrochloride), a vascular ATP-sensitive K+ channel (KATP channel) blocker, were performed on pig urethral myocytes to investigate inhibitory effects on large-conductance intracellular Ca2+ -sensitive K+ channels (i.e., BKCa channels; 225 pS K+ channels) by use of