P0108

PRL-3 Inhibitor I

≥98% (HPLC), solid

• 別名: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone, Phosphatase of regenerating liver-3, Inhibitor I
• 実験式（ヒル表記法）: C₁₇H₁₁Br₂NO₂S₂
• CAS番号: 893449-38-2
• 分子量: 485.21
• MDL番号: MFCD11045303
• UNSPSCコード: 12352200
• PubChem Substance ID: 329820016
• NACRES: NA.77

特性

• 品質水準: 100
• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: protect from light
• 色: yellow
• 溶解性: DMSO: >10 mg/mL; H₂O: <2 mg/mL
• 保管温度: −20°C
• SMILES記法: Brc1ccc(OCc2ccccc2Br)c(c1)\C=C3\SC(=S)NC3=O
• InChI: 1S/C17H11Br2NO2S2/c18-12-5-6-14(22-9-10-3-1-2-4-13(10)19)11(7-12)8-15-16(21)20-17(23)24-15/h1-8H,9H2,(H,20,21,23)/b15-8+
• InChI Key: HXNBAOLVPAWYLT-OVCLIPMQSA-N

詳細

アプリケーション

PRL-3 Inhibitor I has been used as an inhibitor of phosphatase of regenerating liver-3 (PRL-3):

• to test its effect on classical Hodgkin lymphoma cell survival
• in the human umbilical vein endothelial cells tube formation assay
• to test its effect on the migration of neural crest cells

生物化学的／生理学的作用

PRL-3 Inhibitor I is a rhodanine derivative with an IC₅₀ value of 0.9 μM against phosphatase of regenerating liver-3 (PRL-3), a nonclassical protein tyrosine phosphatase that has recently been shown to be involved in cancer metastasis. PRL-3 Inhibitor I reduced the invasiveness of B16F10 melanoma cells in a cell based assay.

特徴および利点

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves